Shining a Light on Intestinal Traffic

Shining a Light on Intestinal Traffic

Inflammatory bowel disease (IBD), encompassing Crohn's disease and ulcerative colitis, is associated with enhanced leukocyte infiltration to the gut, which is directly linked to the clinical aspects of these disorders. Thus, leukocyte trafficking is a major target for IBD therapy. Past and emerging techniques to study leukocyte trafficking both in vitro and in vivo have expanded our knowledge o...

Shining a light on optogenetics

O ptogenetics is relatively new and has attracted much interest since the first publications from the field in the early 2000s. Both researchers and the media are fascinated by the notions it conjures of bionic implants. Notwithstanding potential applications, the technology has quickly become an important research tool in neuroscience with potential for developing a range of novel therapeutic ...

Shining a light on dark data.

1Chris Patil is at the Buck Institute for Age Research, Novato, California, USA 2Vivian Siegel is at the Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA (e-mails: [email protected]; [email protected]) Increasing the publication of dark data will require us to acknowledge and alter the incentives for multiple agents of action: journals, c...

Shining a light on the Sunshine Act.

Shining a light on growth cones

euronal growth cones have detergent-resistant membranes (DRMs), specialized cell membrane fractions enriched in GPI-anchored proteins and intracellular signaling molecules. But are the DRMs involved in regulating neurite outgrowth? Yes, say Nakai and Kamiguchi (page 1097), who developed a new technique for selectively disrupting DRMs, and used it to demonstrate the functional importance of thes...